منابع مشابه
Selectivity for eIF4E
Lattice supports single bilayer he spherical membrane surrounding the poxvirus genome begins to form as an open, cup-like structure. Some have argued that the edge of the cup must be composed of two closely apposed membranes (imagine a collapsed vesicle); otherwise, the hydrophobic edges of a single membrane would be exposed to the cytoplasm. But on page 269, John Heuser confirms that poxvirus ...
متن کاملA role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies.
mRNP remodeling events required for the transition of an mRNA from active translation to degradation are currently poorly understood. We identified protein factors potentially involved in this transition, which are present in mammalian P bodies, cytoplasmic foci enriched in 5' --> 3' mRNA degrading enzymes. We demonstrate that human P bodies contain the cap-binding protein eIF4E and the related...
متن کاملStructural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.
The eukaryotic translation initiation factor eIF4E, a potent oncogene, is highly regulated. One class of eIF4E regulators, including eIF4G and the 4E-binding proteins (4E-BPs), interact with eIF4E using a conserved YXXXXLPhi-binding site. The structural basis of this interaction and its regulation are well established. Really Interesting New Gene (RING) domain containing proteins, such as the p...
متن کاملMnk earmarks eIF4E for cancer therapy.
T he PI3K/Akt/mTORC1 axis is perhaps the most frequently activated pathway in human cancers. Therefore, concerted efforts are being made to inhibit this pathway pharmacologically for cancer therapy. Although some success has been achieved, the multiple feedback loops that “litter” this pathway (ref. 1; Fig. 1), combined with the potential toxicity resulting from its inhibition, make the pharmac...
متن کاملeIF4E as a Control Target for Viruses
Translation is a complex process involving diverse cellular proteins, including the translation initiation factor eIF4E, which has been shown to be a protein that is a point for translational regulation. Viruses require components from the host cell to complete their replication cycles. Various studies show how eIF4E and its regulatory cellular proteins are manipulated during viral infections. ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1692iti5